Fatty Liver
Conditions
Keywords
fatty liver, probiotics, Lactobacillus, fruit, fibre, dietary intervention, obesity
Brief summary
Probiotics and fruit fibre are given for 12 weeks to patients with fatty liver disease. The hypothesis is that probiotic bacteria and fruit fibre affect the gut microbial composition in a positive manner. The improved ecological system is believed to contribute to improved liver health and thereby counteract fatty liver disease.
Interventions
DIETARY_SUPPLEMENTProbiotics and fruit fibre
probiotics and fruit fibre
Sponsors
The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS)
Region Skane
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* be able to participate in magnetic resonance imaging
Exclusion criteria
* unable to understand oral and written information
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improved and normalized liver status | after 12 weeks intervention | normalized concentrations of liver enzymes in plasma. Magnetic resonanse imaging (compared to magnetic resonanse imaging before intervention) will also be used in the investigation of improved liver status. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in the gut bacterial flora | after 12 weeks intervention | Changes and differences of the gut bacterial flora will be addressed in detail, e.g. changes in concentration of specific bacterial groups (e.g. Lactobacillus) before and after the intervention period. |
Countries
Sweden
Outcome results
None listed