Aortic Stenosis
Conditions
Keywords
aortic stenosis, autonomic function
Brief summary
The purpose of this study is to test the prognostic value of autonomic markers in patients with aortic stenosis.
Detailed description
Autonomic function will be assessed by presence of severe autonomic failure (defined by combination of abnormal heart rate turbulence and deceleration capacity). Autonomic function will also be assessed by respiration and repolarization abnormalities.
Interventions
None listed
Sponsors
Thebiosignals.com
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Aortic valve area ≤1.5 qcm or mean aortic gradient ≥25mmHg
Exclusion criteria
* life expectancy \<1 year due to non-cardiac causes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total mortality | 2 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular mortality | 2 years | — |
| Combination of cardiovascular mortality and cardiac adverse events | 2 years | — |
| Correlation of presence of autonomic dysfunction with severity of aortic stenosis | at time of cardiac catheterization, which will be performed at an expected average of 3 days after hospital admission | It will be assessed whether patients with cardiac autonomic dysfunction have more severe aortic stenosis. Autonomic dysfunction will assumed to be present when patients suffer from severe autonomic failure (i.e. combination of abnormal Heart Rate Turbulence and Deceleration Capacity). Severity of aortic stenosis will be assessed by clinical (symptoms, NYHA class), hemodynamic (mean aortic gradient, aortic valve area) and biochemical (Nt-BNP, high sensitive troponins) markers. |
Countries
Germany
Outcome results
None listed