Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01421784

Enrollment

Registered

2011-08-23

Start date

2011-09-30

Completion date

2015-11-25

Last updated

2020-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer

Brief summary

In this study, the researchers investigate the feasibility of using rapid cine MR imaging to provide both offline and online soft-tissue-based image guidance. Such images will provide a significantly more complete picture of the spatial and temporal changes in thoracic anatomy. This more complete information will lay the groundwork for better radiotherapy planning and dose delivery in the presence of respiratory motion.

Detailed description

Rapid MRI scans from Stage I-IV non-small-cell lung cancer (NSCLC) patients will be acquired. MR acquisition will be performed without extrinsically administered contrast, using a balanced turbo field echo (TFE) sequence and commercially available coils.

Interventions

OTHERcine MRI

Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* AJCC Stage I, II, III or IV non-small-cell lung cancer to be treated using radiotherapy will be eligible for this study. * Any types and amounts of prior therapy will be allowed for this study. * Subjects must be greater than or equal to 18 years of age. There are no gender or ethnic restrictions. * Ability to understand and the willingness to sign a written informed consent document. * Able to tolerate supine position * ECOG performance status of 3 or less

Exclusion criteria

* MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical devices e.g., cardiac pacemakers * Women who are pregnant or trying to get pregnant * Pain in supine position

Design outcomes

Primary

Measure	Time frame	Description
To measure time series of MRI imaging by the b-SSFP sequence.	6 weeks	To use fast acquisition sequences to obtain 2D and 3D cine MR images of moving and deforming lung tumors. The signal to noise ration (SNR) and spatiotemporal resolution of imaging sequences will be optimized into a format potentially useful for radiotherapy guidance.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026