Alzheimer's Disease Core Center

Arizona Alzheimer's Disease Core Center

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01421420

Acronym

ADCC

Enrollment

900

Registered

2011-08-22

Start date

2001-07-31

Completion date

2025-07-31

Last updated

2015-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age-Related Memory Disorders, Alzheimer's Disease, Mild Cognitive Impairment

Keywords

Alzheimer's, Dementia, Mild Cognitive Impairment

Brief summary

The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening. All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Detailed description

All participants are seen annually. In addition to a detailed neurological examination, participants will receive a standardized battery of neuropsychological tests and will undergo genetic testing. The investigators will provide standardized periodic longitudinal assessment of the research participants. Autopsies to establish neurohistopathological diagnoses in clinically well-characterized patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

For patients with MCI, or dementia, the presence of cognitive deficits including memory, language, and executive function.

Exclusion criteria

Presence of non-neurological medical conditions interfering with cognition.

Design outcomes

Primary

Measure	Time frame	Description
Neuropsychological Test Scores	Up to 20 years	Cognitive function will be evaluated on a yearly basis using a battery of neuropsychological tests, which will then be scored and normed according to established guidelines.

Secondary

Measure	Time frame	Description
Neurological Exam	Up to 20 Years	A thorough neurological exam will be performed once per year to evaluate neurological function.
Brain Tissue	From date of entry until date of death assessed up to 20 years	A brain autopsy will be performed upon the participant's death to establish histological diagnosis.

Countries

United States

Outcome results