Systemic Effects of Epidural Methylprednisolone Injection on Glucose Tolerance in Diabetic Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01420497

Enrollment

Registered

2011-08-19

Start date

2008-08-31

Completion date

2010-06-30

Last updated

2011-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes, Healthy

Keywords

methylprednisolone, intra articular infiltration, glycemia, epidural infiltration, diabetes

Brief summary

Several studies have shown that in diabetic patients, the glycemic profile was disturbed after intra-articular injection of corticosteroids. Little is known about the impact of epidural injection in such patients. The goal of this study was double, at first comparing the glycaemic profile in diabetic patients after a unique injection of 80 mg of acetate methylprednisolone either intra-articular or epidural, secondly to compare the amount of systemic diffusion of the drug the after both procedures.

Interventions

DRUGintra-articular infiltration

intra articular infiltration

DRUGepidural infiltration

epidural infiltration

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* diabetes stable for more than ten days * no contraindication for steroids * lumbar stenosis * articular pain

Exclusion criteria

* unstable diabetes * renal insufficiency

Design outcomes

Primary

Measure	Time frame
glycemic values,	day 0 to day 15

Secondary

Measure	Time frame
urinary excretion rate	day 0 to day 15

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 27, 2026