Inflammation, Oxidative Stress, Fibrinolytic Markers, Blood Pressure and Cardiorenal Risk Factors
Conditions
Brief summary
Soymilk components such as isoflavones, essential fatty acids, phytoesterols, good fats, inositols might have beneficial effects on controlling complication among diabetic nephropathy patients(DN).Most studies in this regard have been examined the effect of soy consumption on cardiorenal risk factors among patients with DN and there are few data about relationship of soy milk consumption and health effect in patients with DN . Therefore, we evaluated the effects of soy milk compared to cow's milk on blood pressure, inflammation, oxidative stress and fibrinolytic markers and cardiorenal risk factors among these patients. This was a cross-over randomized clinical trial which was conducted in Isfahan among diabetic nephropathy patients. Patients were randomly assigned to consume a diet containing cow's milk or a diet in which only one glass of soy milk was substituted; each one for 4 weeks.
Interventions
DIETARY_SUPPLEMENTsoy milk
DIETARY_SUPPLEMENTcow's milk
Sponsors
Isfahan University of Medical Sciences
Study design
Intervention model
CROSSOVER
Eligibility
Sex/Gender
ALL
Age
28 Years to 81 Years
Inclusion criteria
* adults with (\>18y old) diagnosis of type 2 diabetics nephropathy (diabetics subjects that had proteinuria more than 300 mg/day and had GFR more than 90 mL/min )
Exclusion criteria
*
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| soy milk | — |
Secondary
| Measure | Time frame |
|---|---|
| creatinin | — |
| total cholesterol | — |
| insulin | — |
| systolic blood pressure | — |
| diastolic blood pressure | — |
| Malondialdehyde | — |
| fibrinogen | — |
| Urine creatinine | — |
| urine protein | — |
| HbA1c | — |
| TNF-α | — |
| IL6 | — |
| FBS | — |
| TG | — |
| hs-CRP | — |
| d-dimer | — |
| HDL | — |
| LDL | — |
| BUN | — |
Countries
Iran
Outcome results
None listed