Recurrent Miscarriage
Conditions
Keywords
sildenafil citrate, Doppler Ultrasonography, nitric oxide, total antioxidant capacity
Brief summary
The purpose of this study is to determine whether sildenafil citrate is effective in improving uterine artery blood flow and oxidative stress in patients with unexplained recurrent miscarriages
Interventions
DRUGSildenafil citrate
25 mg orally, 4 times per day for 21 days
DRUGmatching placebo
orally, 4 times per day for 21 days
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-35 years * Three or more recurrent miscarriages before the 24th week of gestation with no apparent cause for their previous losses * Three or more months have elapsed since the last abortion * Postmenstrual period * No other therapy allowed during our treatment course
Exclusion criteria
* Concomitant use of organic nitrites, or nitrates * Severe hepatic, renal, or cardiovascular impairment * History of stroke or myocardial infarction * Patients with retinitis pigmentosa.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Uterine arteries blood flow | 21 days | Uterine arteries blood flow assessed by Doppler U/S by measuring Systolic / diastolic ratio, pulsatility index and resistance index |
Secondary
| Measure | Time frame |
|---|---|
| Nitric oxide serum level as a marked of oxidative stress | 21 days |
| Total antioxidant capacity serum level as a marker of oxidative stress | 21 days |
Countries
Egypt
Outcome results
None listed