Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01419353

Enrollment

Registered

2011-08-18

Start date

2011-08-31

Completion date

2013-06-30

Last updated

2013-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

Infertility, IVF, Estrogen

Brief summary

The purpose of this study is to determine if pretreatment with Estrogen can assist in the planning and programming of In Vitro Fertilization treatments.

Detailed description

A randomised controlled trial in which study group will be given estrogen derivative before ovarian stimulation in GnRH antagonist protocol and compared to the classical GnRH agonist protocol.Estrogen will be given P.O , PROGYNOVA' , in a dose of 2 mg /d, starting day 2 of menses and until first Monday to follow. Main outcome measure will be ability to control the ovum pickup day, calculated as a rate of ideal pickups divided by the entire pickup number. All women enrolled will be under 38 years of age, with a clear indication for IVF other than ovulatory dysfunction. women with past 4 treatment failures will be excluded as well as cases in which sperm achieved in surgical methods.

Interventions

DRUGestradiol valerate

2 mg P.O / day for 1-6 days.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

No minimum to 38 Years

Healthy volunteers

Yes

Inclusion criteria

* IVF treatment in the following indications: Male, Mechanical, Unexplained * Age\<38 years * Treatment Cycle number 1-4

Exclusion criteria

* Ovulatory disorder as an indication for IVF * Repeated failure in previous IVF treatments (\> than 4 cycles) * Sperm used for treatment was retrieved by surgical procedure

Design outcomes

Primary

Measure	Time frame	Description
ovum pickup rate that took place between Sunday to Thursday without a compromise	a year	number of Pickups that took place between Sunday to Thursday (without a compromise in treatment) \\ by the entire pickup number

Secondary

Measure	Time frame	Description
pregnancy rate	a year	comparison of pregnancy rate between the 2 groups. calculated per cycle

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026