Cervical Cancer
Conditions
Keywords
cervical cancer, postoperation, chemotherapy, radiotherapy
Brief summary
The purpose of the research is to evaluate the effect of additional chemotherapy in postoperation therapy of cervical cancer patients with risk factors (big tumor, deep invasion or tumor thrombi in the vascular system).
Detailed description
Cervical cancer has a very high morbidity. Many patients need additional therapy after surgery in order to elevate the survival rate and life quality. In this research, we are going to give additional therapy to patients who have big tumor, deep invasion or tumor thrombi in the vascular system after surgery. randomized control method will be used in this research, in order to compare the survival rate and side effects between radiation therapy only, concurrent chemoradiotherapy, and concurrent chemoradiotherapy with additional chemotherapy. 3D-CRT and Topotecan will be used in this research.
Interventions
None listed
Sponsors
Xi'an Jiaotong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. patients who underwent the cervical cancer radical surgery in three months have higt risk factors which including deep stromal invasion,large primary tumour and/or lymphovascular spase invasion; 2. squamous carcinoma; 3. age\<70; 4. Gynecologic Oncology Group (GOG):0-2.
Exclusion criteria
1. negative nodes,surgical margin,and/or parametrium; 2. No serious damage to the liver and kidney function, no hypertension,diabetes and other effects of therapy complications.
Countries
China
Contacts
Primary ContactLiu Zi, M.D
Backup ContactWang Tao, M.D
Outcome results
None listed