Preliminary Experience of Routine Voriconazole Therapeutic Drug Monitoring (TDM) in a Tertiary Care Centre

Preliminary Experience of Routine Voriconazole Therapeutic Drug Monitoring (TDM) in a Tertiary Care Centre.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01418833

Enrollment

160

Registered

2011-08-17

Start date

2010-10-31

Completion date

2015-01-31

Last updated

2015-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients Treated With Voriconazole

Keywords

voriconazole, therapeutic drug monitoring, plasma levels, dose adjustment

Brief summary

The first goal of this study is to map all the subtherapeutic, therapeutic and supratherapeutic voriconazole plasma levels in the University Hospitals Leuven. The second objective is to optimize and validate guidelines for dose modifications in patients with too low or high plasma concentrations and to investigate if the same guidelines can be used in different patient populations.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients treated with voriconazole * at least 1 voriconazole plasma level measured during therapy

Exclusion criteria

* none

Design outcomes

Primary

Measure	Time frame
Voriconazole plasma levels during routine intravenous and oral therapy	trough levels every 4 days after start or dose adjustment of voriconazole

Countries

Belgium

Outcome results