Dyspnea, Exercise Tolerance, Heart Failure, Pulmonary Hypertension
Conditions
Keywords
cardiac catheterization, echocardiography
Brief summary
Heart Failure with Preserved Ejection Fraction (HFpEF) and Pulmonary Hypertension (PH) can be diagnosed noninvasively by Exercise Echocardiography (ExE) and Cardiopulmonary Exercise Testing (CPX) as compared with gold standard invasive hemodynamic assessment.
Detailed description
* The broad objective of this proposal is to characterize the dynamic changes in cardiopulmonary mechanics during stress in patients with exertional dyspnea, establishing a comprehensive multimodality diagnostic approach to the evaluation of exercise intolerance. * The specific objective is to prospectively compare established and novel parameters derived from echocardiography and CPX with simultaneous, gold standard invasive measures of cardiovascular hemodynamics at rest and with exercise stress to define the role of noninvasive testing in the diagnostic workup. * The primary hypothesis is that combined ExE and CPX can noninvasively identify HFpEF.
Interventions
None listed
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* exertional intolerance/dyspnea of unknown etiology * referral to cardiac catheterization laboratory * undergoing invasive hemodynamic evaluation for clinical purposes
Exclusion criteria
* hypertrophic cardiomyopathy * constrictive pericarditis * infiltrative myopathy (e.g. amyloid) * congenital heart disease * resting LVEF \<50% * \> moderate mitral annular calcification * moderate or greater left-sided valvular stenosis or regurgitation * prior valve surgery * basal septal wall motion abnormalities * \>70% epicardial coronary artery stenosis * right ventricular infarction * pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic Utility ExE and CPX | Same day as clinically indicated Right Heart Catheterization (RHCath) |
Secondary
| Measure | Time frame |
|---|---|
| Multiple integrated measures of cardiovascular function derived from RHCath, ExE and CPX along with rest/exercise natriuretic peptide levels | Same day as clinically indicated RHCath |
Countries
United States
Outcome results
None listed