Non-alcoholic Fatty Liver Disease (NAFLD)
Conditions
Keywords
NAFLD, exercise, hepatic triglycerides
Brief summary
The prevalence of NAFLD is 50-70% in obese people. A decrease of calorie intake and increase of physical activity are recommended as an effective approach for the prevention and treatment of NAFLD. However, the exercise model for NAFLD intervention is understudied. In the present study we aim to compare the effect of intensive and conventional exercise interventions on NAFLD.
Interventions
OTHERIntensive exercise
Subjects conduct an aerobic exercise at 65-80% maximum oxygen consumption for 30 minutes each day, five days a week, totally for 6 months.Subsequently, moderate physical activity(3.0-6.0 MET s) at 150 min/wk for 6 months.
OTHERConventional exercise
Subjects receive moderate physical activity(3.0-6.0 MET s) at 150 min/wk(30 min per day, five days a week) for 12 months.
Sponsors
Shanghai Jiao Tong University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Subjects with NAFLD determined by MRS ; 2. Age 40-65 years old; 3. Waist circumference\> 90cm for men and \> 85cm for women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of intrahepatic triglyceride contents | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| Change of waist circumference | 12 months |
| Change of body fat | 12 months |
| Change of abdominal fat | 12 montshs |
| Change of body weight | 12 months |
| Change of cardiovascular risk factors (Blood pressure, lipids, glucose) | 12 months |
| Change of insulin resistance | 12 months |
| Change of carotid intima-media thickness | 12 months |
Countries
China
Outcome results
None listed