Intraocular Pressure Control After Anterior Segment Laser - Comparison Between 2 Drugs

Short-term Intraocular Pressure Control After YAG Iridotomy - Comparison Between Brimonidine 0.1% vs. 0.2%

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01417858

Enrollment

Registered

2011-08-16

Start date

2010-11-30

Completion date

2012-07-31

Last updated

2011-08-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma, Narrow Angle

Keywords

intra-ocular pressure, iridectomy, gonioscopy, ocular tonometry

Brief summary

The purpose of this study is to compare the intra-ocular (IOP) control efficacy between brimonidine 0.1% vs. 0.2% after laser peripheral iridotomy (LPI).

Detailed description

Postoperative IOP elevation is one of the most common complications after LPI.Previous studies showed that brimonidine 0.2% is effective in blunting IOP spikes after LPI.This prospective randomized double-masked interventional study will include patients with bilateral narrow angles, defined by irido-trabecular contact in \>180o on gonioscopy.Pilocarpine 1% will be used in both eyes, and 30 minutes later, brimonidine 0.1% randomly used in one eye and brimonidine 0.2% in the contra-lateral eye. LPI with Nd:YAG laser is performed 30 minutes later in both eyes by a single glaucoma specialist. IOP measurements are assessed before the use of any eyedrop (basal IOP), 30 minutes after pilocarpine (pre-brimonidine), and 30, 60, 120, 180 minutes after LPI. Pachymetry, ultrasonic biometry, gonioscopy, and total YAG laser energy are recorded. Non-parametric test will be used for analysis.

Interventions

PROCEDUREYAG laser peripheral iridotomy

1 drop 30 minutes before yag laser iridotomy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* bilateral narrow angles, defined by irido-trabecular contact in \>180o on gonioscopy

Exclusion criteria

* previous cataract surgery

Design outcomes

Primary

Measure	Time frame	Description
intra-ocular pressure increase	one year	mean intra-ocular pressure increase after laser peripheral iridotomy

Countries

Brazil

Contacts

Primary ContactLucas Shiokawa, MD

lucasshiokawa@yahoo.com.br55 41 91432398

Backup ContactDayane Issaho, MD

day_issaho@yahoo.com.br

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026