Papillary Thyroid Carcinoma
Conditions
Keywords
papillary thyroid carcinoma, BRAF V600E, poor prognosis, aggressive
Brief summary
The purpose of this study is to determine whether BRAF V600E mutation in our patients with papillary thyroid cancer has an association with poor prognosis.
Detailed description
Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy and BRAF V600E mutation is the most common genetic alteration identified in PTC, ranging from 25 to 80%, with the average rate about 45%. Various studies demonstrated a relationship between BRAF V600E mutation and aggressive characteristics of the cancer, including the worse patient prognosis. But,there are no studies from Turkey regarding this topic. So the investigators will examine BRAF V600E mutation in our patients with PTC and try to assess the role of this mutation in prognosis and further management of the patients.
Interventions
GENETICBRAF V600E POSITIVITY
BRAF V600E mutation analysis will be made using the tumor tissues of the patients with papillary thyroid cancer (3 sections of 7 mm from he paraffin blocks). And mutation positives and negatives will be identified.
Sponsors
Bezmialem Vakif University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with papillary thyroid cancer
Exclusion criteria
* Patients who do not want to be a part of this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BRAF V600E MUTATION | 2 years |
Countries
Turkey (Türkiye)
Outcome results
None listed