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The Optimal Timing of Carbon Dioxide Insufflation During Colonoscopy in Unsedated Patients

The Optimal Timing of Carbon Dioxide Insufflation During Colonoscopy in Unsedated Patients

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01415076
Enrollment
200
Registered
2011-08-11
Start date
2010-09-30
Completion date
2011-06-30
Last updated
2012-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Outpatients

Brief summary

Insufflation of carbon dioxide (CO2) instead of air can reduce pain resulting from colon distension after colonoscopy because CO2 is rapidly absorbed from the colon and excreted through the lungs. This reduces the effects of colonic distension and minimizes intracolonic gas at the end of the examination. The aims of the study were to evaluate the timing of administering CO2 insufflation and to identify predictors of discomfort for colonoscopy.

Interventions

PROCEDUREInsufflation with CO2

Patients were randomly allocated to receive whole procedure or extubation-only CO2 insufflation, using a randomized computer-generated list.

Sponsors

Tri-Service General Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes

Inclusion criteria

* patients with an appropriate indication for colonoscopy were considered eligible.

Exclusion criteria

*

Design outcomes

Primary

MeasureTime frameDescription
abdominal pain during and after colonoscopyOne dayPain was recorded on a ten-point visual analog scale (0- no pain, 10- worst imaginable pain) at left-sided colonoscopic insertion, right-sided colonoscopic insertion, and at 1, 3, 6, and 24 hours postprocedure.

Secondary

MeasureTime frame
delayed bleedingOne day
colonoscopic cecal intubation timeOne day
completeness of intubationOne day
loop formationOne day

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026