Target Site Pharmacokinetics of Doripenem at Steady State in Intubated Intensive Care Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01414959

Enrollment

Registered

2011-08-11

Start date

2011-08-31

Completion date

2013-07-31

Last updated

2017-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal Infection, Pneumonia, Urinary Tract Infection

Keywords

intensive care patient, intubation, (please change wording as you like!)

Brief summary

The investigators will measure the pharmacokinetics of doripenem in skeletal muscle, subcutaneous adipose tissue, bronchoalveolar lavage and plasma of intubated intensive care patients.

Detailed description

Methods: microdialysis, blood sampling, bronchoalveolar lavage

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* endotracheal intubation; pneumonia or complicated abdominal infection or complicated urinary tract infection

Exclusion criteria

* allergy to doripenem, hemodialysis

Countries

Austria

Outcome results