Spontaneous Triggering of Ovulation vs. Administration of Human Chorionic Gonadotropin in Patients Undergoing IUI
Conditions
Keywords
IUI, HCG, Spontaneous LH, pregnancy
Brief summary
We recently reported the superiority of the natural cycle to a natural cycle controlled by the administration of human chorionic gonadotropin (hCG) for planning the frozen-thawed embryo transfer cycles, demonstrating a probable negative impact of exogenous hCG on endometrial receptivity.Based on the above findings we conducted the first prospective study that assesses whether there is a difference in pregnancy rate after intrauterine insemination (IUI) in a natural cycle with spontaneous luteinizing hormone (LH) rise compared to natural cycles controlled by hCG for final ovulation.
Interventions
DRUGHCG
5000 IU
Sponsors
Universitair Ziekenhuis Brussel
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 36 Years
Healthy volunteers
Yes
Inclusion criteria
* age ≤ 36 years, * regular menstrual cycles, * body mass index (BMI) between 18 and 29 kg/m², * basal levels of FSH (≤ 12 IU/l), * estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the cycle, normal hysterosalpingography (maximum 3 months prior starting the cycle). * The use of donor sperm was also accepted as inclusion criteria.
Exclusion criteria
* PCOS * endometriosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ongoing pregnancy rate | 1 year |
Countries
Belgium
Outcome results
None listed