Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer

Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01414595

Enrollment

248

Registered

2011-08-11

Start date

2012-03-31

Completion date

Unknown

Last updated

2017-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer

Keywords

adenocarcinoma of the lung, adenosquamous cell lung cancer, non-small cell lung cancer, squamous cell lung cancer

Brief summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.

Detailed description

OBJECTIVES: * To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens. * To identify and characterize structural variations in the genomes of NSCLC specimens. * To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation. OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.

Interventions

GENETICDNA methylation analysis

GENETICRNA analysis

GENETICDNA analysis

GENETICgene expression analysis

GENETICpolymorphism analysis

OTHERlaboratory biomarker analysis

OTHERmedical chart review

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient must have been registered to CALGB 140202. * Tumor histology should be either primary adenocarcinoma or squamous cell carcinoma of the lung. * Patients are eligible for this study if their samples from CALGB 140202 are available. * All living patients must sign the CALGB 151107 consent form to be eligible for this trial.

Design outcomes

Primary

Measure	Time frame
Identification and characterization of SNVs in primary adenocarcinoma of the lung or squamous cell carcinoma of the lung	up to 5 years
Identification and characterization of structural variations in the genomes of NSCLC	up to 5 years
Identification and characterization of other genomic alterations including, but not limited to, gene expression profiling and methylation	up to 5 years

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026