Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction

Reperfusion Injury and Cardiac Remodelling After Myocardial Infarction in Relation to Adiponectin Level, Circulating Endothelial Progenitor Cells and Endothelial Microparticles

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01414452

Acronym

R²ACE

Enrollment

250

Registered

2011-08-11

Start date

2011-04-30

Completion date

2013-12-31

Last updated

2015-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction, Reperfusion Injury

Keywords

Myocardial Infarction, Reperfusion injury, Adiponectin, endothelial progenitor cells

Brief summary

There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on remodeling, mainly through stimulation of neo-revascularisation. Clinical data on these issues are lacking. This clinical project studies the role of adiponectin, endothelial progenitor cells and endothelial microparticles in the ischaemia-reperfusion process and the compensatory ventricular remodelling in a population of 250 infarction patients treated with primary PCI. If the role of these factors could be confirmed in this clinical setting, those factors might represent a new target for therapeutic interventions in AMI patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* STEMI treated with primary PCI

Exclusion criteria

* ischemia time \>12h * use of immunosuppressive therapy * unsuccessful recanalisation * not-interpretable ST-T segment

Design outcomes

Primary

Measure	Time frame	Description
occurrence of reperfusion injury after succesfull primary PCI	within 90 min after PCI	Serial ECG measurements (before and after PCI to assess extent of ST segment resolution as marker of reperfusion injury

Secondary

Measure	Time frame	Description
Major cardiovascular event rate	at 1 year	combined endpoint of hospitalisation (or extension of hospitalisation) for heart failure and cardiac death in a period of one year

Countries

Belgium

Outcome results