Hibiscus Sabdariffa and Centella Asiatica in the Treatment of Anemia by Iron Deficiency

Prevalence of Genetic Polymorphisms of DMT1 and Ferroportin Enzymes in Adults With Anemia by Iron Deficiency, and Its Influence on the Efficacy of Conventional and Herbal Treatments

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01414374

Enrollment

Registered

2011-08-11

Start date

2012-01-31

Completion date

2013-03-31

Last updated

2015-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Iron Deficiency Anemia

Keywords

iron, anemia, herbal medicine, phytotherapy, Centella asiatica, Hibiscus sabdariffa

Brief summary

The study aims to investigate the prevalence of genetic polymorphisms in adults with iron deficiency and anemia, and the responses to two different treatments: iron sulphate and a composite herbal medicine (Hibiscus sabdariffa plus Centella asiatica). The main outcome will be hemoglobin, measured before and after 6 weeks.

Interventions

DRUGHerbal medicine

Patients will receive a combination of Hibiscus sabdariffa (powdered dry plant), 200 mg, BID, and Centella asiatica tincture, 40 drops, BID, for 6 weeks.

DRUGIron

Patients will receive iron sulphate, 500 mg, BID, plus orange juice, for 6 weeks.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Age \> 18 y and \< 50 y * A diagnostic of iron deficient anemia

Exclusion criteria

* Severe anemia * Treatment interruption for more than 25% of the 6 weeks * New onset severe adverse symptoms or events * Patient's request

Design outcomes

Primary

Measure	Time frame	Description
Hemoglobin	6 weeks	Hemoglobin will be measured before treatment and after 6 weeks of treatment

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026