Depression Suicidal
Conditions
Brief summary
The purpose of this study is to determine whether diclofenac is effective in the treatment of depressed patients with a recent suicide attempt.
Detailed description
The study will start with a feasibility study including treatment of 10 patients with diclofenac.
Interventions
DRUGsugar pill
One tablet two times daily during four weeks
DRUGDiclofenac
50 mg, two times daily (oral adm.) during four weeks
Sponsors
Region Skane
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Depressive disorder * Montgomery Asberg Rating Scale Score more than 20 p. * Recent suicide attempt (Treated as inpatient due to a recent suicide attempt) * Informed consent * Competence to give informed consent
Exclusion criteria
* Pregnancy * Breastfeeding * Serious somatic disease e.g. serious heart, vascular, hepatic, kidney, pulmonary, intestinal, endocrine, haematological or neurological diseases * Ongoing substance abuse * Schizophrenia or other psychotic disorders * Ongoing psychosis * Risk factors for cardiovascular events * Ulcer or gastrointestinal bleeding * Ongoing Electroconvulsive therapy * Previous allergic reaction to NSAID, acetylsalicylic acid, sulfonamides or the diclofenac or sugar pill content * Galactose intolerance, lactase deficiency or glucose-galactose malabsorption * Ongoing treatment with warfarin or other anticoagulants * Ongoing treatment with ACE inhibitors or angiotensin II antagonists Ongoing treatment with drugs known to effect the immune system Ongoing treatment with rifampicin, carbamazepine or barbiturates
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Suicide Assessment Scale (differences in scores before and after treatment) | four weeks of treatment |
Secondary
| Measure | Time frame |
|---|---|
| Barratt Impulsiveness Scale (differences in scores before and after treatment) | four weeks of treatment |
| Montgomery Asberg depression Ratin scale (changes in suicidality item before and after treatment) | four weeks of treatment |
| Montgomery Asberg Rating Scale (differences in scores before and after treatment) | four weeks of treatment |
| Comprehensive Psychopathological Rating Scale (changes in aggressive feelings item before and after treatment) | four weeks of treatment |
| Comprehensive Psychopthological Rating Scale (changes in fatigue item before and after treatment) | four weeks of treatment |
| Montgomery Asberg Rating Scale (changes in concentration item before and after treatment) | four weeks of treatment |
Countries
Sweden
Outcome results
None listed