Effect of Oxygen During Percutaneous Coronary Intervention for Pain Relief

Phase II Randomised Study of Nasal Oxygen Treatment for Pain Relief During Percutaneous Coronary Interventions

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01413841

Acronym

OXYPAIN

Enrollment

300

Registered

2011-08-10

Start date

2011-07-31

Completion date

2012-06-30

Last updated

2012-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angina

Keywords

PCI, oxygen

Brief summary

Nasal oxygen is widely used as pain relief against ischemic pain during Percutaneous Coronary Intervention (PCI). However, to our knowledge no randomised clinical trials have tested this. In contrast, oxygen causes coronary artery vasoconstriction in man. Furthermore, a recent Cochrane meta-analysis has shown no evidence of beneficial effect of oxygen for patients with acute myocardial infarction (with normal blood saturation. The investigators therefore wanted to examine if oxygen reduces ischemic pain during PCI for stable angina or NSTEMI.

Interventions

DRUGNasal oxygen

3 l oxygen

DRUGRegular nasal air

3 l nasal air

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Stable angina or NST-ACS undergoing PCI

Exclusion criteria

* Blood oxygen \<95% * Cognitive dysfunction * STEMI * Intubation

Design outcomes

Primary

Measure	Time frame	Description
Chest pain measured with VAS	1 h	After PCI patient is asked in a double blinded about maximum chest during PCI.

Secondary

Measure	Time frame	Description
Troponin-levels after PCI	2 days	Peak troponin the first days after PCI

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026