Postoperative Wound Infection
Conditions
Keywords
Colorectal surgery, Surgical site infection, Symbiotic
Brief summary
The objective of the study is to investigate whether peri-operative symbiotic treatment could reduce the risk of postoperative infections in patients undergoing elective colorectal surgery. This study was also designed to assess the risk-adjusted incidence and predictors of surgical site infections.
Interventions
BIOLOGICALSymbiotic
Oral symbiotic every 8 h since 2 days before operation; Symbiotic resumes postoperatively on day +2 until day +4 for a total of 4 d of treatment (12 doses).
Sponsors
Mashhad University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
14 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Both genders 2. More than 14 years old 3. Candidate for elective colorectal surgery
Exclusion criteria
1. Denied written informed consent, 2. Severe neutropenia, and 3. Critically ill condition 4. Not meeting inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of post-operative infection after elective colorectal surgery among patients with and without pre-operative symbiotic conditioning. | 15 months |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative infection including surgical site infections (SSIs) and distant-site infections after elective colorectal surgery in patients whether or not receiving pre-operative symbiotic conditioning. | 15 months |
Outcome results
None listed