Endometrial Scratching in Couples With Unexplained Subfertility

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01412606

Acronym

ESUS

Enrollment

105

Registered

2011-08-09

Start date

2009-07-31

Completion date

2011-06-30

Last updated

2012-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subfertility

Keywords

Unexplained infertility-endometrial scratching, effect of endometrial biopsy (scratching) on clinical pregnancy rates in women with unexplained infertility

Brief summary

Endometrial scratching in luteal phase of a spontaneous menstrual cycle may increase pregnancy rate in women with unexplained infertility.

Interventions

PROCEDUREscratching

scratching endometrium on day 21-26 of a spontaneous menstrual cycle

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 39 Years

Healthy volunteers

Inclusion criteria

* women aged between 20 and 39 years with at least one year of infertility * regular menstruation with the length of the cycle between 22-34 days and ovulation confirmed by appropriately timed mid-luteal progesterone * fertile semen variables * bilateral tubal patency (demonstrated by laparoscopy or hysterosalpingography).

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate	6 months

Secondary

Measure	Time frame
miscarriage rate	6 months

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026