Endothelial Dysfunction, Insulin Resistance, Metabolic Syndrome, Peripheral Arterial Disease
Conditions
Keywords
Sedentarism, Physical inactivity, Fish oil, Omega-3 fatty acids, Endothelial dysfunction, Insulin resistance, Metabolic syndrome, peripheral arterial disease
Brief summary
The purpose of this study are twofold: 1. To understand the effects of physical inactivity (sedentarism) on vascular function, insulin resistance and inflammation; 2. To assess the role of a dietary intervention (fish oil) in counteracting the effects of physical inactivity on vascular function and inflammation.
Interventions
DIETARY_SUPPLEMENTFish Oil (Omega-3 Fatty Acids)
fish oil-4.4gm/day x 5 days
Sponsors
University of California, San Francisco
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects: Subjects must be free from any acute, chronic or debilitating medical conditions. Healthy status will be established on the basis of clinical history, electrocardiogram, clinical biochemical screening tests of blood and urine, a physical examination, and where necessary a chest radiograph.
Exclusion criteria
* Any active acute or chronic medical problem: Any subject with symptoms of active illness (e.g., fever, leukocytosis, hypertension) will be excluded from study. The
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial Function | 5 days | Flow-mediated, brachial artery vasodilation (FMD) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin Resistance | 5 days | The homeostatic model assessment (HOMA) method used to quantify insulin resistance (HOMA-IR) |
Countries
United States
Outcome results
None listed