Effect of Saccharomyces Boulardii on Indirect Hyperbilirubinemia and Phototherapy Duration in Very Low Birth Weight Infants

Phase 4 Study of Saccharomyces Boulardii on Indirect Hyperbilirubinemia

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01411761

Enrollment

Registered

2011-08-08

Start date

2011-05-31

Completion date

2011-12-31

Last updated

2011-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Indirect Hyperbilirubinemia

Keywords

indirect hyperbilirubinemia, very low birth weight infants

Brief summary

Indirect hyperbilirubinemia is frequently observed in premature infants.Probiotics are favorable microorganisms that regulate the flora of the gastrointestinal system. In this study we aimed to compare the effect of S. boulardii on severity of hyperbilirubinemia and duration of phototherapy on very low birth weight infants.

Interventions

DIETARY_SUPPLEMENTReflor

5 million unit/day, first 15 day of life

OTHERserum physiologic

1 cc added to one feeding in a day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

1 Days to 15 Days

Healthy volunteers

Inclusion criteria

* very low birth weight infants

Exclusion criteria

* chromosomal anomalies

Design outcomes

Primary

Measure	Time frame
Effect of S. boulardii on severity of hyperbilirubinemia and phototherapy duration	6 months

Secondary

Measure	Time frame
long term effect of S.boulardii on neurodevelopmental outcome	6 months

Countries

Turkey (Türkiye)

Contacts

Primary ContactGamze Demirel, MD

kgamze@hotmail.com+905324540156

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026