Heart Failure, Congestive, Heart Failure With Preserved Ejection Fraction
Conditions
Brief summary
BACKGROUND: Exercise intolerance is the primary symptom in older patients with heart failure and preserved ejection fraction (HFPEF), however little is known regarding its mechanisms and therapy. METHODS: 71 elderly stable, compensated HFPEF patients (age 70+1 years; 80% women) with controlled blood pressure were randomized into a 12 month follow-up (FU) double-blind trial of enalapril 20 mg per day (E) vs. placebo (P). Assessments included: peak exercise oxygen consumption (VO2); six-minute walk test; Minnesota Living with HF Questionnaire (MLHF); MRI; Doppler-echocardiography; and vascular ultrasound.
Interventions
DRUGEnalapril
2.5mg titrated up to 10mg twice daily
DRUGplacebo
2.5mg titrated up to 10mg twice daily.
Sponsors
Wake Forest University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All participants will be 60 years of age or older.
Exclusion criteria
1. systolic dysfunction 2. patients with evidence of significant ischemic or valvular heart disease 3. chronic pulmonary disease. Participants who appear preliminarily eligible are invited to a formal screening visiting with an investigator cardiology physician. They also undergoing a rest and exercise electrocardiogram and echocardiogram and pulmonary function testing as well as blood hematology and chemistry tests. Final eligibility will be based upon all information available at the conclusion of the screening visits test, including hospital and outpatient records, history, physical examination, echocardiogram and exercise test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| exercise capacity and aortic distensibility | 9 months | MRI and expired gas analysis |
Outcome results
None listed