Obesity
Conditions
Keywords
Obesity, Adolescent, Exercise training, Exercise tolerance
Brief summary
Worldwide, childhood and adolescent obesity has reached epidemic proportions despite major efforts to promote weight reduction. Pediatric obesity commonly presages adult obesity and is associated with the development of weight-related comorbid conditions and increased morbidity. Regular physical activity is an important modality of obesity management. Despite controversies, poor exercise tolerance has frequently been reported in youth obesity and the cause of this limited exercise tolerance remains unknown. Several factors accompanying obesity may interfere with exercise tolerance in obese populations. Respiratory factors, such as decreased thoracic compliance, increased airway resistance and breathing at low pulmonary volumes are associated with obesity and may impact exercise intolerance in this population. Moreover, even in people with otherwise normal lungs, the normal ventilatory responses to exercise can become constrained in obesity. A thorough understanding of the mechanisms underlying this exercise intolerance remains fundamental in order to favour long term adherence to exercise training. This is especially true in youth populations, in which the management of overweight and obesity must be undertaken as soon as possible, due to the early onset of cardiovascular risk factors. The main purpose of this study is to determine early-onset cardio-respiratory mortality factors in obese adolescents as well as their relation with exercise intolerance (i.e. dyspnea) when compared with age and gender-paired normal-weight volunteers.
Detailed description
Physiopathological trial. Expected total enrollment : 20 obese adolescents + 20 control subjects Tested treatment: Exercise training (4 hours per week). Treatment duration: 12 weeks
Interventions
BEHAVIORALExercise training
12-week supervised exercise-training (ET) program consisting of two 60-min and one 120-min exercise sessions per week which focus mainly on aerobic exercises (cycling, treadmill, rower). Initial aerobic exercise intensity is set at 60 % of HR peak and will reach 80 % at the end of the ET protocol.
Sponsors
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and female obese adolescents (BMI \> IOTF 30, 12-16 years old)
Exclusion criteria
* Cardiovascular pathology * Pathology interfering with physical activity (neurological pathology, severe respiratory illness i.e. asthma, renal failure) * Diabetes (known or treated) * Participation in another study * Asthma (known and treated)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exercise tolerance (Expiratory flow limitation and Operational Lung Volumes at rest and exercise, cardiorespiratory and subjective responses to incremental exercise) | Participants will be followed for the duration of exercise training, an expected average of 12 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Polysomnography | Participants will be followed for the duration of exercise training, an expected average of 12 weeks | Explore the potential existence of obstructive sleep apnea and its effects on cardiovascular adaptations during exercise. |
| Cardiorespiratory fitness (VO2max) | Participants will be followed for the duration of exercise training, an expected average of 12 weeks | — |
Countries
France
Outcome results
None listed