Vitamin D Deficiency
Conditions
Keywords
Vitamin D Deficiency, HIV+ Children, HIV+ Young Adults
Brief summary
The relationship of Vitamin D levels in children and young adults to atherosclerosis.
Interventions
None listed
Sponsors
Emory-Children's Center
University Hospitals Cleveland Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
8 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
- Documentation of HIV Infection Between ages of 8 and 25 * On stable ART for at least 12 weeks for the HIV+ patients * Cumulative duration of ART for at least 48 weeks for HIV + patients * Healthy child/young adult with age and race matched to HIV+ patient for the HIV- controls * Absence of HIV based on medical and medication history
Exclusion criteria
* Taking \> 800 IU of Vitamin D per day * Parathyroid or Calcium disorders * Acute illness and active inflammatory condition * Chronic illnesses that include malignancy, diabetes, CAD * Pregnancy and lactation * Creatinine Clearance \<50 ml/min * Hgb \< 9.0 g/dL * AST and ALT \> 2.5 upper limits of normal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vitamin D levels | One time point at entry | To perform a cross-sectional analysis of blood vitamin D status among the HIV-infected children and young adults to evaluated the point prevalence fo plasma 25(OH)D levels indicating vitamin D insufficiency, deficiency and severe deficiency, and to compare the prevalence to a matched uninfected healthy control group. |
Countries
United States
Outcome results
None listed