Local Anesthetic Infiltration and Infusion for Pain Control After Hip Replacement

The Evaluation of the Efficacy of Local Infiltration Analgesia and Infusion for Total Hip Arthroplasty

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01409278

Enrollment

105

Registered

2011-08-04

Start date

2009-08-31

Completion date

2011-06-30

Last updated

2011-08-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Brief summary

The purpose of this study is to examine three different ways to control pain after hip replacement: 1. One time injection of ropivacaine before wound closure 2. One time injection of ropivacaine before wound closure plus slow release of ropivacaine via catheter for 48 hours 3. Standard practice of patient controlled pump

Interventions

PROCEDURERopivacaine infiltration and saline infusion.

50ml ropivacaine 0.2% with keterolac 15mg infiltration followed by normal saline infusion at 5ml per hour

PROCEDURERopivacaine infiltration and infusion.

50 ml infiltration of ropivacaine 0.2% and ketorolac 15mg admixture followed by ropivacaine 0.2 % at 5ml per hour infusion for 48 hours.

PROCEDURENormal Saline

50ml of normal saline infiltration followed by normal saline infusion at 5ml per hour

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* total knee replacement

Exclusion criteria

* History of neurological disease, diabetes, pregnancy, allergy to local anesthetic solutions chronic narcotic use ability to consent

Design outcomes

Primary

Measure	Time frame
The pain medication requirement for 48 hours after surgery in three groups.	48 hours after surgery

Secondary

Measure	Time frame
Pain scores, incidence of nausea and vomiting and patient satisfaction in each group.	48 hours after surgery

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026