Running Effect on Cardiovascular and Muscular Parameters

Effect of 16 Weeks of Running Exercise on Parameters Related to the Cardiovascular System, Blood and Muscle in Untrained Males 30-50 Years Old. A Randomized Controlled Study

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01406730

Enrollment

Registered

2011-08-01

Start date

2011-07-31

Completion date

2012-07-31

Last updated

2012-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

30-50 Years Old, Healthy, Males, Untrained

Keywords

running exercise, cardiac hypertrophy, blood, maximum oxygen uptake, intervention, untrained, males

Brief summary

The purpose of the study is to determine the effect of 16 weeks of running exercise on various parameters related to heart, vascular systems, blood, and muscle in untrained males 30-50 years old. Further, the investigators assess which of the above mentioned parameters may explain the increase of running performance most accurate.

Interventions

OTHERexercise

16 week of periodized progressive running exercise 2-4 times/week

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

30 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* males * untrained (\< 2 endurance exercise sessions/week) * 30-50 years old

Exclusion criteria

* pathological changes of the heart * inflammable diseases * medication/diseases affecting cardiovascular system and muscle * very low physical capacity (\< 100 Watt at ergometry) * obesity (BMI \> 30 kg/m2) * more than 2 weeks of absence during the interventional period * more than 2 exercise session beside the intervention * contraindication related to MRI-assessment (i.e. claustrophobia, magnetizable intracorporal artefacts)

Design outcomes

Primary

Measure	Time frame	Description
myocardial mass/stroke volume	4 month	Atrial and ventricular volume and mass indexes were assessed by magnetic resonance imaging (MRI)

Secondary

Measure	Time frame	Description
maximal oxygen uptake	4 month	maximal oxygen uptake during running
Resting metabolic rate	4 month	Adaptation of resting metabolic rate to running exercise
muscle strength/power	4 month	Isometric muscle strength of the leg extensors Leg power as assessed by counter movement jump
myocardial volume	4 month	Functional and morphologic parameters of the heart as assessed by echocardiography
Intima media thickness	4 month	Carotid intima media thickness by high-resolution ultrasound

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 5, 2026