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Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT01406041
Enrollment
350
Registered
2011-07-29
Start date
2011-02-28
Completion date
2021-05-12
Last updated
2020-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Fluid and Electrolyte Imbalance Happened After Surgery, The Patients Suffered With Sellar Diseases

Keywords

Fluid and electrolyte imbalance, Hyponatremia, Hypernatremia, Electrolytes disorder

Brief summary

The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions. Moreover, if the patients are undergone the surgery for remove the lesion, FEI happens in all cases without exception. Hypo- and hyper-natremia is the most common electrolyte disorder, which is directly correlated to the patients' outcome. However, in clinical works, different sellar diseases cause variant features of FEI. For example, after the surgery of craniopharyngioma, the hyponatremia and hypernatremia always happen alternatively even without any precursor manifestation. Under this situation, it is quite difficult for fluid supplement. In contrast, the severe FEI will cause poor outcome, even death. So it is necessary to systematically collect and review the clinical data of sellar lesions. Through the analysis of variant FEI patterns of sellar diseases, more precise strategy for clinical fluid replacement will be proposed.

Interventions

BIOLOGICALChemical and physical detection

CVP, Urine volume per day, Blood electrolytes, Urine sodium per day, Pituitrin

Sponsors

Southern Medical University, China
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* 1\. Suffered with sellar disease * 2\. Udergone surgery * 3\. Have sufficient presurgical and postsurgical clinical data (Including MRI, CT, physical and chemical detection results)

Exclusion criteria

* 1\. Without sufficitent clincal data * 2\. No surgery

Design outcomes

Primary

MeasureTime frameDescription
Blood sodium24 hoursNormal: 135\ 155

Secondary

MeasureTime frame
Urine sodium48 hours

Countries

China

Contacts

Primary ContactYuntao Lu, PI
lllu2000yun@gmail.com+86-13632101002

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026