The Impact of Obesity on Nonsurgical Periodontal Therapy

The Impact of Obesity on Nonsurgical Periodontal Treatment of Destructive Periodontal Diseases

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01405365

Enrollment

Registered

2011-07-29

Start date

2009-08-31

Completion date

2012-12-31

Last updated

2011-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis, Periodontal Diseases, Obesity

Keywords

Periodontitis, Periodontal diseases, Obesity, Metronidazole, Prognosis, Probing depth, Periodontal attachment loss

Brief summary

The purpose of this study is to investigate the effect that obesity may have on the nonsurgical treatment (with and without the adjunct use of metronidazole) of destructive periodontal diseases (chronic periodontitis).

Detailed description

Normal weight (BMI 18.5-24.9 kg/m2) and obese (BMI \>30 kg/m2) women will be randomly assigned to two nonsurgical periodontal treatments: 1. scaling and root planing + placebo 2. scaling and root planing + metronidazole

Interventions

DRUGMetronidazole

Metronidazole 400mg TID for 10 days

DRUGPlacebo

Placebo pill TID for 10 days

PROCEDUREScaling and root planning

Scaling and root planning performed with curettes and ultrasonic scalers under local anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

FEMALE

Age

35 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Normal weight or obese (according to BMI) * nonsmokers or former smokers (3 or more years) * no systemic diseases that may affect periodontal treatment (diabetes, osteoporosis, steroid use) * have 10 teeth present * have at least 2 teeth with probing depth 6+mm and attachment loss 4+mm

Exclusion criteria

* Pregnancy * Development of diabetes or other conditions that may impair periodontal healing

Design outcomes

Primary

Measure	Time frame	Description
Probing depth	12 months	Defined as the distance from the free gingival margin to the bottom of the pocket/sulcus.

Secondary

Measure	Time frame	Description
Attachment level	12 months	Defined as the distance from the CEJ to the bottom of the pocket/sulcus.

Countries

Brazil

Contacts

Primary ContactEduardo J Gaio, DDS

dudagaio@hotmail.com55 51 9252 4577

Backup ContactJuliano Cavagni, DDS

jcavagni@hotmail.com55 54 8111 9440

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026