Functional MRI of Relaxation Response Training in Adults With Attention-Deficit/Hyperactivity Disorder

Functional MRI of an Open Trial of Relaxation Response Training in Adults With Attention-Deficit/Hyperactivity Disorder

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01404273

Acronym

ADHD

Enrollment

Registered

2011-07-28

Start date

2009-09-30

Completion date

2011-09-30

Last updated

2013-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ADHD

Brief summary

This research study is being done to examine how meditation and the relaxation response (RR) may change brain activity in attention-deficit/hyperactivity disorder (ADHD).

Interventions

BEHAVIORALMeditation/Relaxation Response Training

1 hour weekly sessions with 20 min daily home practice for 6 weeks

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 49 Years

Healthy volunteers

Inclusion criteria

1. Male or female adults (ages 18 - 49). 2. Patients with the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), by the Diagnostic and Statistics Manual of Mental Disorders (DSM-IV), as manifested in clinical evaluation and confirmed by structured interview.

Exclusion criteria

1. Any current, non-ADHD Axis I psychiatric conditions 2. Baseline Beck Depression Inventory (BDI) \> 19. 3. Any clinically significant chronic medical condition. 4. Mental retardation 5. Organic brain disorders 6. Seizures or tics. 7. Pregnant or nursing females. 8. Clinically unstable psychiatric conditions (suicidal behaviors, psychosis). 9. Current or recent (within the past 2 years) substance abuse or dependence. 10. Patients currently or recently (within past 1 month) on psychotropic medication. 11. Subjects with current or prior adequate psychopharmacologic treatment for ADHD. 12. Regular practice of an Relaxation Response-inducing technique within the past year 13. History of claustrophobia or any of the standard contraindications to magnetic resonance imaging (MRI) scanning(metal objects within body).

Design outcomes

Primary

Measure	Time frame	Description
Change in functional magnetic resonance imaging (fMRI) activation from baseline after a 6-week intervention	2 sessions, 2 hours each to be conducted before and after the 6-week intervention	functional magnetic resonance imaging (fMRI) activation in dorsal anterior medial cingulate cortex (daMCC) & dorsolateral prefrontal cortex (DLPFC) during multi-source interference task (MSIT)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026