Renal Failure, Acute
Conditions
Brief summary
The primary objective of this study is to compare the efficacity of hemodiafiltration and hemofiltration for decreasing plasma urea at 12h among intensive care patients. Secondary objectives include comparing urea clearance, filter duration, and %down-time, between the two techniques.
Interventions
PROCEDUREHemodiafiltration first
Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemodiafiltration.
PROCEDUREHemofiltration first
Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemofiltration.
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* According to RIFLE score, patient is stage 'F' * The patient must be insured or beneficiary of a health insurance plan * The patient meets at least one of the following criteria: * metabolic acidosis (pH \< 7.2), excluding keto-acidosis * plasma urea \> 25 mmol/l * hyper-hydration is not controlled by diuretics
Exclusion criteria
* Chronic, terminal renal insufficiency with dialysis * The patient is under judicial protection, under tutorship or curatorship * Suspect hyperkaliemia (Kaliemia \> 6.5 mmol/l with electrocardiographic effects) * Intoxications treated via dialysis * Pregnant, lactating, parturient women * Medical indication for localized citrate anticoagulation * dialysis of less than 12 h * patient or representative refuses to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%. | 12 hours | Proportion of dialysis sequences for which the rate of plasma urea reduction \> 60%. Rate of plasma urea reduction = (initial urea concentration - urea concentration after 12h our dialysis)/initial urea concentration. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of dialysis sequences for which the rate of plasma urea reduction > 60%. | 24 hours | Proportion of dialysis sequences for which the rate of plasma urea reduction \> 60%. Rate of plasma urea reduction = (initial urea concentration - urea concentration after 12h our dialysis)/initial urea concentration. |
| Urea clearance (ml/min) for the dialysis sequence under study | 12 hours | Urea clearance (ml/min) for the dialysis sequence under study. |
| Filter lifespan (hours) for the dialysis sequence under study. | 12 hours. | Filter lifespan (hours) for the dialysis sequence under study. |
| The percentage down-time for the first 24 hours of dialysis | 24 hours | The percentage down-time for the first 24 hours of dialysis = (number of hours where the exchange is not effective / 24 hours)\*100 |
| Fluid replacement (yes/no) | 12 hours | Was fluid replacement necessary during the studied dialysis sequence? |
Countries
France
Outcome results
None listed