Healthy
Conditions
Brief summary
The primary objective of this study is to evaluate the reproducibility of a method of measuring blood flow rates to the tracheo-bronchial mucosa using diluted dimethyl ether as a tracer.
Interventions
BIOLOGICALBlood flow to the tracheo-bronchial mucosa
Measurement of blood flow to the tracheo-bronchial mucosa via differential absorption of diluted dimethyl ether tracer gas.
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* The patient must have given his/her informed and signed consent * The patient must be insured or beneficiary of a health insurance plan
Exclusion criteria
* The patient is under judicial protection, under tutorship or curatorship * The patient refuses to sign the consent * It is impossible to correctly inform the patient * Patient is pregnant * Patient is breast feeding * The patient is a smoker * The patient has, or has a history of, chronic respiratory insufficiency * The patient has a contra-indication for a treatment necessary in this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The reproducibility of two measures of Qaw at a five minute interval | Five minutes | Qaw is the blood flow measured in the tracheobronchial mucosa. Qaw = VDME/(FDME\*alpha\*10s) where VDME is the volume of dimethyl-ether exhaled (ml), FDME is the mean concentration of dimethyl-ether (%), alpha is the Bunsen coefficient for the dissolution of dimethyl ether in tissues and blood at 37°C (i.e. 9ml/ml). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The time necessary to complete one measure of Qaw (minutes) | Day 1 | Qaw = blood flow measured in the tracheobronchial mucosa |
Contacts
PRINCIPAL_INVESTIGATORCharles Le Merre, MD
Centre Hospitalier Universitaire de Nīmes
Outcome results
None listed