PREdictive Value of COntrast voluMe to creatinINe Clearance Ratio

Conditions

Contrast Induced Nephropathy

Keywords

contrast-induced nephropathy, contrast medium, creatinine clearance, coronary angiography, diabetes, chronic kidney disease

Brief summary

To determine a relatively safe contrast media volume to creatinine clearance cut-off value to avoid contrast-induced nephropathy in patients following coronary angiography

Detailed description

Contrast media volume to creatinine clearance (V/CrCl) ratios were obtained from consecutive consenting patients after coronary angiography. Receiver-operator characteristic (ROC) curves were used to identify the optimal sensitivity for the observed range of V/CrCl. The predictive value of V/CrCl for the risk of contrast-induced nephropathy was assessed using multivariate logistic regression.Subgroup analysis was performed on patients with creatinine clearance \< 60 ml/min,diabetes,emergent angiography.

Liwei Liu, Jin Liu, Li Lei, Bo Wang, Guoli Sun et al. (15 authors)

BMC Cardiovascular Disorders2020-08-317 citations

10.1186/s12872-020-01689-6

Random forest for prediction of contrast-induced nephropathy following coronary angiography.

Liu Y, Chen S, Ye J, Xian Y, Wang X, Xuan J, Tan N, Li Q, Chen J, Ni Z.

2020-04-133 citations

10.1007/s10554-019-01730-6

Early β-blockers administration might be associated with a reduced risk of contrast-induced acute kidney injury in patients with acute myocardial infarction

Jin Liu, Guoli Sun, Yibo He, Feier Song, Shiqun Chen et al. (12 authors)

Journal of Thoracic Disease2019-04-0113 citations

10.21037/jtd.2019.04.65

Association of post-procedural early (within 24h) increases in serum creatinine with all-cause mortality after coronary angiography.

Guo XS, Chen SQ, Duan CY, Li HL, Bei WJ, Liu Y, Tan N, Chen PY, Chen JY.

2017-09-014 citations

10.1016/j.cca.2017.08.036

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* patients who agreed to stay in the hospital for 2-3 days after coronary angiography * provided written informed consent

Exclusion criteria

* pregnancy * lactation * intravascular administration of an contrast medium within the previous seven days * treatment with metformin,aminoglycosides,N-acetylcysteine (NAC),nonsteroidal anti-inflammatory drugs within the previous 48 h * intake of nephrotoxic drugs within the previous seven days * history of serious reactions to contrast mediums， severe concomitant disease renal transplantation , or end-stage renal disease necessitating dialysis * patients who died during coronary angiography

Design outcomes

Primary

Measure	Time frame	Description
Contrast-Induced Nephropathy	48-72 h	Contrast-Induced Nephropathy was defined as an increase in serum creatinine of more than 0.5 mg/dl from the baseline within 48-72 h of contrast exposure

Secondary

Measure	Time frame	Description
An early abnormal increase in serum creatinine	24h	An early abnormal increase in serum creatinine defined as an increase in serum creatinine of more than 0.5 mg/dl from the baseline within 24h of contrast exposure
Major adverse clinical events	1 year	Major adverse clinical events: death, requiring renal replacement therapy, 2nd myocardial infarction,target revascularization,acute heart failure, mechanical ventilation,2nd angina,tachyarrhythmia,hypotension,intra-aortic balloon pump and stroke
An early abnormal increase in serum cystatin C	24h	An early abnormal increase in serum cystatin C was defined as an increase more than 10% from the baseline within 24h of contrast exposure

Countries

China

Outcome results