Irritable Bowel Syndrome
Conditions
Brief summary
The purpose of the present study is to study the effect of aloe vera in the treatment of IBS patients in a randomized, double-blind placebo controlled study.
Detailed description
There is limited knowledge of the IBS pathophysiology, absence of biological markers and therefore few effective treatment options. IBS therefore contributes to difficulties in the management of the patients. Aloe vera has a long association with herbal medicine, from the Ebers Papyrus from 16th century BCE. It is alleged to be effective in treatment of wounds, to improve blood glucose levels in diabetics, and it may reduce symptoms and inflammation in patients with ulcerative colitis. Evidence of the effects of aloe vera in the treatment of IBS, is however limited and contradictory.
Interventions
DIETARY_SUPPLEMENTAloe vera effervescent tablet (AVH200)
250 mg aloe vera and 60 mg ascorbic acid, Aloe Life®
DIETARY_SUPPLEMENTPlacebo control
60mg Ascorbic acid
Sponsors
Calmino group AB
Sahlgrenska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* IBS according to the Rome III criteria * Adults
Exclusion criteria
* other GI disorders * other medical conditions * were pregnancy or breast-feeding * food allergy or intolerance to other than lactose * ongoing intake of aloe vera products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IBS symptoms | 4 weeks |
Countries
Sweden
Outcome results
None listed