Pentraxin-3 in Chronic Renal Failure

The Role Pentraxin-3 in the Inflammatory Process in Chronic Renal Failure, and the Association With Other Inflammatory Parameters

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01397773

Enrollment

Registered

2011-07-20

Start date

2010-04-30

Completion date

2011-01-31

Last updated

2011-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease, Inflammation

Keywords

Hemodialysis, peritoneal dialysis, chronic kidney disease, inflammation, carotis intima media thickness

Brief summary

The aim of the study is to measure Pentraxin-3 levels in patients on hemodialysis, peritoneal dialysis and those in the pre-dialysis period; and to compare these groups with the control group; so as to investigate the eligibility of it as a reliable marker of inflammation; relationship with other inflammatory markers and carotis intima media thickness.

Detailed description

The investigators planned to involve four group of patients: Hemodialysis, peritoneal dialysis, pre-dialysis and the control group; with about 25 patients planned to be involved in each group. The laboratory parameters to be measured are Pentraxin-3, C-reactive protein (CRP), high sensitive CRP, fibrinogen and interleukin-6. Concomitantly, carotis intima media thickness will be measured in the radiology clinic. Statistical analysis will be carried on by Statistical Package for Social Sciences (SPSS) for Windows 13.0. The variables acting on the inflammatory parameters and the correlation between them and carotis intima media thickness will be studied.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

16 Years to 80 Years

Healthy volunteers

Inclusion criteria

* To give informed consent * Hemodialysis or peritoneal dialysis for more than 3 months * Creatinin clearance less than 30 ml/min for the pre-dialysis group

Exclusion criteria

* Not to give informed concent * Active infection within the last 3 months * Known chronic inflammatory disease

Design outcomes

Primary

Measure	Time frame	Description
Pentraxin-3 level	Five months	Pentraxin-3 level will be compared with other inflammatory markers.

Secondary

Measure	Time frame	Description
Carotis intima media thickness	Five months	Correlation of Pentraxin-3 and carotis intima media thickness

Countries

Turkey (Türkiye)

Outcome results