Cocaine Dependence
Conditions
Keywords
Transcranial Magnetic Stimulation, Cocaine, impulsivity, rating scale
Brief summary
In a randomized, double-blind controlled trial the investigators will evaluate the efficacy of rTMS in reducing impulsivity for cocaine addicts through - Quantitative and qualitative analysis - such behavior and possible behavioral consequences related.
Detailed description
reduction of the rating impulsivity
Interventions
PROCEDURETranscranial Magnetic Stimulation
ACTIVE rTMS delivered to the left dorsolateral prefrontal cortex
PROCEDUREPlacebo TMS
PLACEBO rTMS delivered to the left dorsolateral prefrontal cortex
Sponsors
University of Sao Paulo General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
1. Diagnosis of the cocaine dependence syndrome, alone or in combination with abuse of alcohol and nicotine dependence (DSM IV, 1994; SCID-P, 1994). 2. 20 days or less withdrawal 3. 18-35 years old. 4. If female, to be using contraception (barrier, oral contraceptive, IUD, surgical sterilization). 5. Fixed residential address in Sao Paulo
Exclusion criteria
1. Other Mental Disorders (DSM IV, 1994; SCID-P, 1994). 2. organic brain disease, neurosurgery to implant metal clip or epilepsy. 3. severe uncontrolled clinical comorbidity. 4. use current or within last six months of psychotropic drugs in general, except for Clonazepam dose of up to four mg / day. 5. Changes clinically significant laboratory findings. 13 6. Condition or situation to which in the opinion of the investigator put the patient at risk significant, which may confound the results, or interfere substantially in individual's participation in the study. 7. Mandate that mandating the judicial treatment for cocaine dependence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Short PROMIS Questionnaire | 2 months | The SPQ is a 160-question paper that counsellors and researchers can use to measure an individual's level of addictive tendency in each of sixteen distinct behavioural areas. Will be applied at the following times: T0 (weeks 0 - immediately prior to the rTMS) T1 (4 weeks, after four weeks of treatment with rTMS) and T2 (8 weeks, four weeks after completing treatment). The improvement rate of 10% or more, will be our primary measure of efficacy. T0 ( |
Countries
Brazil
Contacts
Primary ContactÁdan Jardim
Outcome results
None listed