Shock
Conditions
Keywords
PiCCO
Brief summary
PiCCO has become a widely used haemodynamic monitoring device in the management of shock patients in ICU patients nowadays. But the effects on outcome of use of Picco, such as hospital mortality, vasoactive agents-free days, intensive care unit, and mechanical ventilation-free days and change of lactate and BNP in shock patients has not been determined. Patients will be randomly assigned to a Picco group or the control group, hospital mortality, vasoactive agents-free days, intensive care unit, and mechanical ventilation-free days and change of lactate and BNP will be observed. The conclusion will supply evidence for the clinical effectiveness of Picco in shock patients.
Interventions
DEVICEPiCCO
transpulmonary thermodilution technique
OTHERsham, no intervention
no intervention
Sponsors
Li danyang
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* critically ill patients with shock: Mean arterial pressure (MAP) \< 65 mmHg (\< 8,7 kPa) or systolic arterial pressure (SAP) \< 90 mmHg (\< 12 kPa) or the need for vasopressor (Norepinephrine \<0.05µg/kg/min) to support the MAP ≥ 65 mmHg (≥ 8,7 kPa) or the SAP ≥ 90 mmHg ≥ 12 kPa), when one of these criteria has lasted for 4 hours or longer
Exclusion criteria
* Age \< 18 years * Age \> 85 years * Pregnancy (positive pregnancy test in women of child bearing age)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mortality at 28 days | 28 days | mortality at 28 days after diagnosis of shock |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| intensive care unit-free days | 28 days | intensive care unit(ICU) free days, defined as the number of days from day 1 to day 28 without ICU stay. |
| mechanical ventilation-free days | 28 days | ventilator free days: the number of days from day 1 to day 28 during which the patient breathed spontaneously |
| vasoactive agents-free days | 28 days | vasoactive agents-free days: the number of days from day 1 to day 28 without use of vasoactive agents. |
| the change of B-Type Natruetic Peptide(BNP) at 1,3,7 days after the insertion of the Picco catheter | 7 days | blood samples will be taken before the insertion of the Picco catheter and everyday after the insertion, the change of BNP at 1,3,7 days after the insertion of the Picco catheter will be collected. |
| mortality at 90 days | 90 days | mortality at 90 days after diagnosis of shock |
| the change of lactate at 1,3,7 days after the insertion of the Picco catheter | 7 days | blood samples will be taken before the insertion of the Picco catheter and everyday after the insertion, the change of lactate at 1,3,7 days after the insertion of the Picco catheter will be collected. |
Countries
China
Contacts
Primary ContactCui Wei, MD
Backup ContactLi Danyang, MD
Outcome results
None listed