Brain Diseases, Brain Injuries, Central Nervous System Diseases, Craniocerebral Trauma, Trauma, Nervous System
Conditions
Keywords
TBI, Acute physical exercise, Cognitive functions, Mood
Brief summary
The aim of this study is to determine the effects of an acute session of physical exercise on cognitive functioning and humor of traumatic brain injury patients and to investigate whether different cognitive responses can be achieved with different intensities of exercise (moderate and vigorous). The investigators hypothesize that while moderate intensity physical exercise may be beneficial to cognitive functioning, vigorous intensity may be detrimental to TBI patients, as physical fatigue may impair alertness and other higher cognitive functions.
Detailed description
It is well known the benefits of physical exercise to cognitive functioning, which have been demonstrated in animal studies and in those with healthy humans or with individuals with some type of pathology. Nevertheless, there are few studies investigating the effects of acute physical exercise on cognitive functions of people with traumatic brain injury, even though they frequently have impairments in several cognitive domains due to their brain damage. The effect of two intensities of physical exercise (moderate and exhaustive) in attention, processing speed, memory, executive control and decision making will be investigated in patients with TBI. For that matter, their performance will be compared to non-brain injured subjects submitted to the same protocol and to TBI patients submitted to a stretching session. Each subject will be submitted to a neuropsychological evaluation before and after the physical exercise in order to determine if there is an improvement in cognitive performance post-exercise.
Interventions
BEHAVIORALAcute Physical Exercise
Patients and healthy volunteers will be submitted to a protocol of progressive maximal exercise until voluntary exhaustion and one weak later to 30 minutes of physical exercise in ventilatory threshold I, both in the same cycloergometer.
BEHAVIORALStretching protocol
TBI patients will be submitted to 30 minutes of stretching exercises composed of 15 exercises that prioritize back, legs and hip.
Sponsors
Federal University of São Paulo
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
Patients with TBI eligible for participation in this research study must meet the following inclusion criteria: Inclusion Criteria: * diagnose of moderate to severe TBI * be at least six-months post-injury * have a neurologist that allowed to enroll into the study * be able to take part in a cycloergometer-protocol, attested by the laboratory (CEPE) physician * brain injury must have occurred in adult life * provided written informed consent for participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuropsychological evaluation | 1 Day | Neuropsychological evaluation will be held immediately before the execution of physical exercise (maximal, 30 minutes in ventilatory threshold I or stretching exercise) and immediately after the conclusion of exercise. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mood, fatigue and impulsivity questionnaires | 1 day | Mood, fatigue and impulsivity questionnaires will be held immediately before the execution of physical exercise (maximal, 30 minutes in ventilatory threshold I or stretching exercise) and immediately after the conclusion of exercise |
Countries
Brazil
Contacts
Primary ContactPatricia Rzezak, PhD
Outcome results
None listed