Macular Edema
Conditions
Keywords
Post-cataract surgery, macular edema
Brief summary
Assess prophylactic efficacy of topical non-steroidal anti-inflammatory drops in preventing macular edema. Patient undergoing uncomplicated cataract surgery will be enrolled and randomized to nepafenac, ketorolac, or placebo. Follow-up will occur at 1 month with ocular coherence tomography (OCT).
Interventions
DRUGNepafenac 0.1%
1 drop QID for 1 month
DRUGKetorolac 0.5%
1 drop QID for 1 month
OTHERPlacebo (sterile saline drops)
1 drop QID for 1 month
Sponsors
Queen's University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Ability to give informed consent * Age 18 years and older
Exclusion criteria
* Any pre-existing retinal disease (e.g., diabetic retinopathy, vein occlusion, exudative macular degeneration, etc.) * Previous uveitis * Previous intraocular surgery * Allergy or hypersensitivity to NSAIDs * Complicated cataract surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in macular volume (as quantified by OCT) at one month (compared to baseline) | baseline and one month after surgery |
Secondary
| Measure | Time frame |
|---|---|
| COMTOL health-related quality-of-life | one month after surgery |
Countries
Canada
Outcome results
None listed