Effect of Ketamine Added to Intravenous Patient-controlled Analgesia on Postoperative Pain, Nausea and Vomiting in Patients Undergoing Lumbar Spinal Surgery

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01394406

Enrollment

Registered

2011-07-14

Start date

2010-01-31

Completion date

2012-04-30

Last updated

2014-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea and Vomiting

Brief summary

Ketamine added to intravenous patient-controlled analgesia may be effective on prevention of postoperative nausea and vomiting by reducing opioid requirement after surgery.

Interventions

DRUGKetamine

ketamine 3 mg/kg mixed to intravenous patient controlled analgesia device (fentanyl 20 mcg/kg. total volume 180 ml, basal infusion 2 ml, bolus 2ml, lock-out 15 min)

DRUGSaline

equal volume of normal saline mixed to intravenous patient controlled analgesia device

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Non-smoking female patients undergoing elective lumbar spinal surgery * Age 20-65 * American Society of Anesthesiologists physical status classification I or II

Exclusion criteria

* Antiemetic within 24 hrs, Taking Steroids, Opioids within 1 week * Psychiatric disease, Active drug or alcohol abuse * GI motility disorder, severe renal/ hepatic disease * insulin-dependent DM * admission to ICU after surgery

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative nausea and vomiting	within 48 hrs after surgery

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026