Pulmonary Hypertension
Conditions
Keywords
respiratory therapy, exercise therapy, oxygen uptake, quality of life, right ventricular function, severe pulmonary hypertension
Brief summary
Aim of this study is to investigate whether and to what extent a cautious respiratory and exercise therapy can complement medical treatment and change the condition, oxygen uptake, quality of life, the pulmonary vascular pressures, the size of the right heart and the 6-minute walk distance in patients with pulmonary hypertension.
Interventions
Conventional therapy with diet, massage, relaxation baths, plus easy strolls specific respiratory and physical therapy plus mental walking training
Sponsors
Heidelberg University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Consent form * men and women\> 18 years \<75 years * invasively confirmed chronic PH who have received complete diagnostic evaluation by specialized doctors / physicians according to the WHO classification at a center for pulmonary hypertension and were adjusted for 2 months under intensive medical therapy and are stable.
Exclusion criteria
* Pregnancy or lactation * Change in medication during the last 2 months * Patients with signs of right heart decompensation * severe walking disturbance * uncertain diagnoses * No previous invasively confirmation of PH * acute diseases, infections, fever * Serious lung disease with FEV1 \<50% or TLC \<70% of target * Further
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of peak O2 uptake (VO2peak) under stress | up to 15 weeks | Three-week inpatient rehabilitation, continuation of the training program for another 12 weeks at home (exercise group), patients in the control group continued their usual activities. After 15 weeks, training is also offered to patients in the control group. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in hemodynamics at rest and during exercise | up to 15 weeks | 1. Changes in hemodynamics at rest and during exercise after three weeks and 15 weeks: RAP, RVP, sPAP, DPAP, mPAP, PCWP, cardiac output, PVR, CI, SvO2 2. Changes in exercise capacity: 6-minute walk distance, Recumbent Bike (Watts), respiratory economy (EQO2, EQCO2) 3. Improved condition(NYHA class, Borg scale) 4. Changes in MRI and echocardiographic parameters of right and left ventricle: size and pump function. 5. Change of laboratory parameters, which are markers of right heart failure as NTproBNP, interleukins |
Countries
Germany
Outcome results
None listed