Computed Tomography Versus Exercise Testing in Suspected Coronary Artery Disease

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01393028

Acronym

CRESCENT

Enrollment

350

Registered

2011-07-13

Start date

2011-07-31

Completion date

2014-08-31

Last updated

2014-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angina Pectoris, Chest Pain

Keywords

coronary artery disease, angina pectoris, Stable chest pain complaints

Brief summary

Direct non-invasive coronary imaging by computed tomography (CT) has the potential to improve the workup of patients with stable chest pain complaints. The objective of the study is to compare in a randomized fashion the effectiveness and efficiency of a CT angiographic driven workup of suspected coronary artery disease in comparison to the standard workup using stress testing.

Interventions

OTHERCardiac CT

Cardiac CT: calcium scan and CT coronary angiography

OTHERStandard care

Standard care according to international guidelines

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Men and women aged \>18 years. * Stable symptoms of chest pain or dyspnea potentially caused by obstructive CAD.

Exclusion criteria

* A history of surgical or percutaneous coronary revascularization * Non-revascularized angiographic obstructive coronary artery disease (\>50% diameter reduction). * Normal invasive coronary angiography or stress imaging less than 1 years ago. * Inability or unwillingness to provide informed consent.

Design outcomes

Primary

Measure	Time frame	Description
Chest pain	1 year	Reduction of chest pain symptoms by standardized questionnaire, at one year follow-up
Class IA Revascularizations	1 year	Number of revascularizations with an ESC class 1A indication

Secondary

Measure	Time frame	Description
Radiation dose	1 year	Cumulative radiation exposure at one year
Overall medical expenses	1 year	Overall medical expenses
Quality of life	1 year	Change of quality of life at 1 year
Major adverse cardiovascular events	1 year	Composite endpoint of adverse cardiovascular events, including: All-cause mortality Non-fatal myocardial infarction Unstable angina requiring hospital admission Late revascularization procedures (\>6 months after initial evaluation)
Cost-effectiveness	1 year	Cost-effectiveness analysis based on the overall quality of life and medical expenses at one year.

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 27, 2026