Cardiovascular Disease, Hyperhomocysteinemia
Conditions
Keywords
Hyperhomocysteinemia, Chronic kidney disease
Brief summary
It is well recognized that patients with chronic kidney disease (CKD) have an increased risk for cardiovascular disease (CVD) and hyperhomocysteinemia appears to be a predictor of future CVD events. Hyperhomocysteinemia has been reported to bo of high prevalence in patients with CKD. The investigators aim to study the prevalence of hyperhomocysteinemia in Thai CKD patients by using Thai Screening and Early Evaluation of Kidney Disease (SEEK) study database and their relationship to CVD.
Detailed description
Ninety eight subjects were sampling from Thai SEEK study database Traditional Traditional risk factors of CVD such as total cholesterol, triglyceride, age, sex, history of smoking and blood pressure levels were examined and recorded. Stored sera of these subjects were analyzed for the total homocysteine (tHcy) level. Analysis of variance was used to evaluate the different of mean tHcy among groups
Interventions
None listed
Sponsors
Bangkok Metropolitan Administration Medical College and Vajira Hospital
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* CKD stages 3-4 from Thai SEEK Study
Exclusion criteria
* CKD stage 5
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of Homocysteine | 3 months | Level of homocysteinemia according to each CKD level |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association of cardiovascular event to the level of homocysteine | 3 months | Hugh level of homocysteine will have association with cardiovascular events or not |
Outcome results
None listed