Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer

Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer: a Randomized Controlled Trial

Status

Withdrawn

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01389986

Enrollment

Registered

2011-07-08

Start date

2011-07-31

Completion date

2013-09-30

Last updated

2016-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paralytic Ileus

Brief summary

Following extensive abdominal surgery for the treatment of endometrial or ovarian cancer, paralytic ileus frequently develops. Gum chewing can promotes the return of bowel function through the cephalic-vagal reflex and increased intestinal enzymes secretion. The objectives of this study are to evaluate effects of adding gum chewing to the conventional postoperative feeding protocol on the return of bowel function, its related complications, and patients' satisfaction.

Interventions

BEHAVIORALGum chewing

Gum chewing (30 minutes in duration each time, 4 times/days at the usual time of meal, until the first flatus) in addition to conventional postoperative feeding schedule

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing staging or cytoreductive surgery for primary endometrial or ovarian cancer at Maharaj Nakorn Chiang Mai hospital

Exclusion criteria

* Perioperative hyperalimentation * Recent chemotherapy (within 3 weeks before surgery) * Previous bowel surgery * Inflammatory bowel diseases * Previous abdominal or pelvic radiation * Need for immediate postoperative endotracheal intubation * Need for postoperative admission to intensive care unit * Undergoing emergency surgery with oral intake of fluid or food within 4 hours before surgery

Design outcomes

Primary

Measure	Time frame
Time to first flatus	Up to 7 days after surgery

Secondary

Measure	Time frame
Incidence of postoperative complications	Up to 7 days after surgery
Time to first regular diet	Up to 7 days after surgery
Time to first defecation	Up to 7 days after surgery
Incidence and severity of postoperative nausea, vomiting,and abdominal discomfort	Up to 7 days after surgery
Hospital stay	On the day of hospital discharge, an expected average of 7 days
Patients' satisfaction	Up to 7 days after surgery
Postoperative analgesics requirement	Up to 7 days after surgery

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026