Angina Pectoris, Left Ventricular Wall Motion Abnormalities
Conditions
Keywords
coronary stenosis, Angina pectoris, left ventricular wall motion abnormalities
Brief summary
The investigators will check the feasibility of an intraprocedural vitality diagnostics and the identification of an indication for Percutaneous transluminal coronary angioplasty (PTCA).
Detailed description
After myocard vitality diagnostics with MRI patients will underwent additionally an stress echocardiography within the exploration. By this ultrasound we will measure the LV mass and the ejection fraction per apical 2-, 3- and 4-chamber view. In addition a 2D-strain-analysis will be done to measure the systolic and diastolic strain and also the circumferential and radial strain rate parameter (by depicting three parasternal short axis views in the basal, mid-ventricular and apical plane). These measurements will be compared with the studies-conditioned MRI-finding (as reference) to find the optimal strain-parameter and the optimal cut-off-data for an intraprocedural vitality diagnostics of the single layers (endocardial, myocardial, and epicardial) for this patient group. The data upraised through this are compared off-line to the MRI findings.
Interventions
PROCEDURE2D-strain echo
2D-strain-analysis with elevation of the radial and circumferential strain and strain rate parameter(systolic and diastolic)occurs through the echocardiography. Comparison of the echocardiography and the MRI-vitality data, calculation of a cut out of vision value of a vitality diagnosis with the help of 2D-strain-analysis.
Sponsors
RWTH Aachen University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* left ventricular wall motion abnormalities * existent myocardial vitality MRI exploration * reduced LV-function * steady angina pectoris * patients which are legally competent and which are mentally able to understand the study staff * patients give their written consent
Exclusion criteria
* pregnancy or lactation * acute or instable angina pectoris * acute myocardial infraction in the last 3 month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cut-Off-Value of vital myocardial tissue | time during hospitalization | It will be determine cutt-off-value of vital myocardial tissue in comparison to MRI myocardial vitality findings. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| feasibility and safety of echocardiography during catheter investigations | time during hospitalization and 1 months afterwards | it will be analyzed if it is logistically possible to perform echo-test during the actual catheter investigations (feasibility) and if the patient will be exposed to any safety risk for logistic or sterility reasons. |
| Determination of Strain-Parameter for identification of vital myocardial tissue | time during hospitalization | It will be determitated optimal Strain-Parameter(circumferential, systolic or diastolic)for identification of vital myocardial tissue |
Countries
Germany
Outcome results
None listed