Migraine With Aura
Conditions
Keywords
Migraine with aura
Brief summary
Recently, there is evidence that endothelial activation and dysfunction are associated with migraine, especially in female migraineurs with aura. Our objectives were to determine whether novel endothelial function markers are altered in female migraineurs with aura compared to age-matched controls.
Detailed description
Our objectives were to determine whether novel endothelial function methods and novel markers of endothelial activation are associated with migraine in female migraineurs with aura. Migraine is an independent risk factor for stroke, especially in young women with aura symptoms. Endothelial dysfunction is a risk factor for cardiovascular diseases. Recent studies suggest that there is a link between migraine with aura and endothelial activation, dysfunction and impaired vascular reactivity. In this case-control study the investigators examine several novel biomarkers of endothelial function such as endothelial progenitor cells and endothelial microparticles as well as novel methods such as reactive hyperemic peripheral arterial tonometry in female migraineurs with aura and age-matched controls.
Interventions
None listed
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* migraine with aura * age \< 50 * female gender
Exclusion criteria
* severe infectious disease * cardiovascular disease (stroke, coronary heart disease, myocardial infarction) * vasculitis * peripheral artery disease * diabetes mellitus * pregnancy * drug abuse * medication: statin, anticoagulation, aspirin, clopidogrel * intake of triptans \<24h
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial Microparticles | baseline | Levels of endothelial microparticlel in the peripheral blood using flow cytometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Levels of circulating Endothelial Progenitor Cells | baseline | Levels of cEPC (CD34+/CD133+/VGF2R/CD31) in % of mononuclear cells using flow cytometry |
| Digital pulse volume change | baseline | Digital pulse volume change (with RH PAT as non invasive measurement (PAT-ratio; ENDOPAT, Itamar Medical Ltd.) for non-invasive, peripheral endothelial function |
Countries
Germany
Outcome results
None listed